Elevated levels of troponin I by high-sensitivity assay (hs-TnI) may predict mortality over the next 2 weeks Cam Atkinson Jersey , but not over the longer term, among patients with sepsis when measured during the first four days of an intensive care unit (ICU) stay, a new study suggests[1].The results are from a prospective cohort study that excluded people with clinically apparent causes of troponin a secondary finding, patients with elevated hs-TnI showed a significantly increased risk for future new-onset or worsening cardiovascular (CV) disease, as indicated by subsequent jump in use of CV onins are not routinely measured in ICU patients with sepsis, but when they are measured Matt Calvert Jersey , elevations are common, Dr Olaf L Cremer (University Medical Center Utrecht, The Netherlands) told | Medscape Cardiology.
"That seems to have an impact on prognosis," based on the current analysis, said Cremer, senior author on the study's publication January 29 in Circulation: Cardiovascular Quality and Outcomes with lead author Dr Jos F Frencken (University Medical Center Utrecht)."We think this is a real signal Alexander Wennberg Jersey ," even with the study's limitations. "Whether it is truly causal or just an association, we're not entirely certain, because this is observational data," he said."The main message that we wanted to convey is that it might be worthwhile to monitor troponin to some extent, as a prognostic factor, and to be aware of late implications of this myocardial injury."Patients with raised troponins during sepsis could be at later risk for some form of cardiac dysfunction and therefore might benefit from cardioprotective therapy. But what form such treatment might take isn't known Zach Werenski Jersey , according to least, he said, "They should have some follow-up by a cardiologist a few months after they've left the hospital. That would be a first strategy to try, probably."But it would be premature to recommend routine troponin testing in ICU patients with sepsis because what to do with the information is unknown, observed Dr Allan S Jaffe (Mayo Clinic, Rochester Jack Johnson Jersey , MN), who was not involved in the current study."However, studying it, and trying to figure out what might be done, might be terribly helpful," he said when interviewed. "There's tremendous information there Sergei Bobrovsky Jersey , we just have to learn how to use it better."Currently, once elevated troponins are observed, "the one place where there might be something actionable, one could argue, would be downstream once patients have left the hospital," said Jaffe Artemi Panarin Jersey , echoin